Human-mouse cell hybrids: a suggestion of structural mutation for dipeptidase-2 deficiency in mouse cells.

Science (New York, N.Y.) ·Vol. 178 ·No. 4056 ·1972-10-06 ·Pages 58-60

Shows TB, May J, Haley L

Abstract

The dipeptidase-2 enzyme is inactive in certain cultured cell lines from the mouse. In somatic cell hybrids between such deficient cells and diploid human fibroblasts, the mouse deficiency was complemented when the homologous human peptidase-A was retained. The results suggested that the murine peptidase deficiency was the result of a structural mutation, rather than a regulatory one.

MeSH Terms

Animals Cell Line Connective Tissue Dipeptidases/analysis,biosynthesis Electrophoresis, Starch Gel Fibroblasts Genes Genes, Regulator Humans Hybrid Cells/enzymology Lung Mice Mutation Phenotype

Chemicals

Dipeptidases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Shows T B

May J

Haley L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.178.4056.58

Published

1972-10-06

Pages

58-60

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.178.4056.58 View journal details

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Human-mouse cell hybrids: a suggestion of structural mutation for dipeptidase-2 deficiency in mouse cells.

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