Prostaglandin-like activity in ocular inflammation.

British medical journal ·Vol. 3 ·No. 5824 ·1972-08-19 ·Pages 452-3

Eakins KE, Whitelocke RA, Bennett A, Martenet AC

Abstract

Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patients treated with steroids, and none (<2 ng/ml) was detected in aqueous from the uninflamed eyes of patients with cataract. Alkaline hydrolysis of the samples from inflamed eyes suggested the presence of both E and F prostaglandin-like activity. These results show that prostaglandins may be involved in acute anterior uveitis.

MeSH Terms

Alkalies Animals Aqueous Humor/metabolism Biological Assay Cataract/metabolism Humans Hydrolysis Muscle Contraction Muscle, Smooth/drug effects Prostaglandins/metabolism Rats Steroids/therapeutic use Stomach/drug effects Uveitis/drug therapy,metabolism

Chemicals

Alkalies Prostaglandins Steroids

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Eakins K E

Whitelocke R A

Bennett A

Martenet A C

References (8)

8 references, click to expand

A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.
Br J Pharmacol Chemother. 1968;33:162-70 PMID: 12310175
The effects of prostaglandins on the intraocular pressure of the rabbit.
Br J Pharmacol. 1969 Sep;37(1):158-67 PMID: 4981000
Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye.
Exp Eye Res. 1970 Jul;10(1):87-92 PMID: 5456783
Recovery of prostaglandins in human cutaneous inflammation.
Br Med J. 1971 May 1;2(5756):258-60 PMID: 5572386
Effects of prostaglandins and a prostaglandin antagonist on intraocular pressure and protein in the monkey eye.
Can J Ophthalmol. 1971 Jul;6(3):205-11 PMID: 4998497
Extraction of prostaglandins from human blood.
Nature. 1971 Oct 1;233(5318):336-7 PMID: 4940429
Further studies on the effect of prostaglandin on intraocular pressure in the rabbit.
Exp Eye Res. 1971 Mar;11(2):170-7 PMID: 5001095
A sensitive method for the assay of 5-hydroxytryptamine.
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9 PMID: 13460242

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5824.452

Published

1972-08-19

Pages

452-3

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1785983

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5824.452 PMC Full Text

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