Hodgkin-Huxley axon. Increased modulation and linearity of response to constant current stimulus.

Biophysical journal ·Vol. 12 ·No. 9 ·1972-09-00 ·Pages 1145-58

Shapiro BI, Lenherr FK

Abstract

Repetitive response patterns resembling those of tonic receptors were obtained by increasing the potassium system time constant in the Hodgkin-Huxley (H-H) equations. The increase in time constant varied with membrane potential. Calculated spike frequencies varied linearly with the magnitude of the constant current stimulus; in addition, minimum frequencies were greatly reduced, and the frequency range increased. Modification of the maximum ionic conductances, membrane capacitance, and rate constant voltage dependence was found to vary the minimum frequency, current at that frequency, slope, and over-all modulation of the modified responses.

MeSH Terms

Axons/physiology Electric Stimulation Ion Exchange Kinetics Membrane Potentials Models, Biological Potassium/physiology

Chemicals

Potassium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Shapiro B I

Lenherr F K

References (14)

14 references, click to expand

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Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(72)86151-4

Published

1972-09-00

Pages

1145-58

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1484140

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(72)86151-4 PMC Full Text View journal details

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Hodgkin-Huxley axon. Increased modulation and linearity of response to constant current stimulus.

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