Comparison of the blocking potency of local anesthetics applied at different pH values.

Experientia ·Vol. 28 ·No. 4 ·1972-04-15 ·Pages 419-20

Frazier DT, Murayama K, Narahashi T

Abstract

暂无摘要

MeSH Terms

Action Potentials Anesthetics, Local/pharmacology Animals Axons/drug effects Hydrogen-Ion Concentration Lidocaine/pharmacology Mollusca Procaine/pharmacology

Chemicals

Anesthetics, Local Procaine Lidocaine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Frazier D T

Murayama K

Narahashi T

References (3)

3 references, click to expand

On the mode of action of local anesthetics.
Annu Rev Pharmacol. 1966;6:405-30 PMID: 5324859
Cationic forms of local anaesthetics block action potentials from inside the nerve membrane.
Nature. 1969 Aug 16;223(5207):748-9 PMID: 5802688
Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons.
Toxicol Appl Pharmacol. 1967 May;10(3):529-47 PMID: 6059668

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF02008313

Published

1972-04-15

Pages

419-20

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF02008313

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Comparison of the blocking potency of local anesthetics applied at different pH values.

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