Cytochalasin B: inhibition of D-2-deoxyglucose transport into leukocytes and fibroblasts.

Science (New York, N.Y.) ·Vol. 176 ·No. 4042 ·1972-06-30 ·Pages 1432-4

Zigmond SH, Hirsch JG

Abstract

Cytochalasin B inhibits transport of (D)-2-deoxyglucose and of glucosamine into kukocytes, but does not impair uptake of kucine by these cells. This inhibitory action is rapid and reversible, and results in suppression of glycolysis. Cytochalasin B also blocks transport of (D)-2-deoxyglucose, but not of leucine, into mouse L strain fibroblasts.

MeSH Terms

Animals Autoradiography Carbon Isotopes Glucosamine/metabolism Glycolysis/drug effects Hexoses/metabolism Horses Kinetics L Cells/metabolism Lactates/biosynthesis Leucine/metabolism Leukocytes/metabolism Mice Mycotoxins/pharmacology Tritium

Chemicals

Carbon Isotopes Hexoses Lactates Mycotoxins Tritium Leucine Glucosamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zigmond S H

Hirsch J G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4042.1432

Published

1972-06-30

Pages

1432-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4042.1432 View journal details

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Cytochalasin B: inhibition of D-2-deoxyglucose transport into leukocytes and fibroblasts.

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