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PMID: 50322 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20).

The Journal of biological chemistry ·Vol. 250 ·No. 15 ·1975-08-10 ·Pages 6002-7

Burd JF, Larson JE, Wells RD

Abstract

The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20) are described. Thermal denaturation studies on these DNAs in the absence and presence of actinomycin, which binds only to the GC portions of these molecules, have confirmed and extended our previous observation that the properties of one region of a DNA can be influenced (telestabilized) by a remote region. In addition, the large scale synthesis of d(C15A15) - d(T15G15) is described.

MeSH Terms

Animals Cattle Chromatography, Gel Coliphages/enzymology DNA/biosynthesis DNA Nucleotidyltransferases/metabolism DNA Viruses/enzymology Dactinomycin/pharmacology Deoxyribonucleases Deoxyribonucleotides Drug Stability Hot Temperature Nucleic Acid Denaturation Oligonucleotides/biosynthesis Pancreas/enzymology Polynucleotides/biosynthesis Thymus Gland/enzymology

Chemicals

Deoxyribonucleotides Oligonucleotides Polynucleotides Dactinomycin DNA DNA Nucleotidyltransferases Deoxyribonucleases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Burd J F

Larson J E

Wells R D

Article Info

Journal

The Journal of biological chemistry

Abbr.

J Biol Chem

ISSN

0021-9258

Published

1975-08-10

Pages

6002-7

Language

English

Region

United States

NLM ID

2985121R

Subset

External Links

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Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20).

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