Neuromuscular transmission: inhibition by manganese ions.

Science (New York, N.Y.) ·Vol. 176 ·No. 4032 ·1972-04-21 ·Pages 308-9

Meiri U, Rahamimoff R

Abstract

Manzganiese ions. are potent blocking argenits of synaptic transmission at the neuromuscular junction in the frog. The main site of action is the presynaptic nerve terminal, where the ions decr-ease the amount of transmitter liberated by a never impulse. The inihibition produced by manganese is reversible.

MeSH Terms

Action Potentials/drug effects Animals Anura Calcium/pharmacology In Vitro Techniques Manganese/pharmacology Motor Neurons/drug effects Neuromuscular Depolarizing Agents Neuromuscular Junction/drug effects

Chemicals

Neuromuscular Depolarizing Agents Manganese Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Meiri U

Rahamimoff R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4032.308

Published

1972-04-21

Pages

308-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4032.308 View journal details

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