Coronary vasodilator responses to hypoxia before and after aminophylline.

The Journal of physiology ·Vol. 221 ·No. 3 ·1972-03-00 ·Pages 589-99

Afonso S, Ansfield TJ, Berndt TB, Rowe GG

Abstract

1. In previous studies adenosine has been postulated to be the mediator in coronary blood flow regulation and aminophylline was found to inhibit the coronary vasodilator action of adenosine. The present study was performed to determine whether aminophylline inhibits coronary vasodilatation induced by hypoxia.2. Coronary and systemic haemodynamic and metabolic effects of hypoxia were studied in anaesthetized dogs before and after aminophylline. Aminophylline did not influence coronary vasodilatation induced by hypoxia.3. These results are held not to lend support to the hypothesis that adenosine is the metabolite responsible for the regulation of coronary blood flow.

MeSH Terms

Adenosine/pharmacology,physiology Aminophylline/pharmacology Animals Blood Pressure Cardiac Output Coronary Circulation/drug effects Dilatation Dogs Femoral Artery Heart Rate Hypoxia/physiopathology Myocardium/metabolism Oxygen/blood Oxygen Consumption/drug effects Pulmonary Artery Vascular Resistance/drug effects

Chemicals

Aminophylline Adenosine Oxygen

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Afonso S

Ansfield T J

Berndt T B

Rowe G G

References (6)

6 references, click to expand

A thermodilution flowmeter.
J Appl Physiol. 1966 Nov;21(6):1883-6 PMID: 5929318
Release of adenosine in reactive hyperemia of the dog heart.
Am J Physiol. 1969 Jan;216(1):56-62 PMID: 5765591
Coronary vasodilator responses to hypoxia and induced tachycardia before and after lidoflazine.
Am J Physiol. 1969 Feb;216(2):297-300 PMID: 5766980
Release of adenosine by the normal myocardium in dogs and its relationship to the regulation of coronary resistance.
Circ Res. 1969 Oct;25(4):407-15 PMID: 5347222
Inhibition of coronary vasodilating action of dipyridamole and adenosine by aminophylline in the dog.
Circ Res. 1970 Jun;26(6):743-52 PMID: 4987265
Inhibition of cardiovascular metabolic and hemodynamic effects of adenosine by aminophylline.
Am J Physiol. 1970 Dec;219(6):1672-4 PMID: 4922147

Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1972.sp009769

Published

1972-03-00

Pages

589-99

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1331353

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1972.sp009769 PMC Full Text View journal details

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Coronary vasodilator responses to hypoxia before and after aminophylline.

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