Studies on the biological properties of polyene antibiotics. Evidence for the direct interaction of filipin with cholesterol.

Acholeplasma laidlawii/drug effects,metabolism Antifungal Agents/pharmacology Calorimetry Carbon Isotopes Cell Membrane/drug effects Cell Membrane Permeability Cholestanes Cholesterol/metabolism Erythrocytes/drug effects Fatty Acids Humans Hydrogen-Ion Concentration Lactones Membranes Membranes, Artificial Permeability Phosphatidylcholines Spectrophotometry Sterols Structure-Activity Relationship Surface Tension Ultraviolet Rays

Antifungal Agents Carbon Isotopes Cholestanes Fatty Acids Lactones Membranes, Artificial Phosphatidylcholines Sterols Cholesterol