Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide.

Science (New York, N.Y.) ·Vol. 175 ·No. 4018 ·1972-01-14 ·Pages 198-9

Stewart SE, Kasnic G, Draycott C, Ben T

Abstract

Dimethyl sulfoxide added to cultures first treated with 5-iododeoxyuridine increased C-type virus production approximately tenfold in a human rhabdomyosarcoma cell line. 5-Iododeoxyuridine followed by dimethyl sulfoxide also activated a similar C-type virus in a metastatic tumor from a bronchial node taken from a 52-year-old male.

MeSH Terms

Adenocarcinoma/microbiology Cells, Cultured Deoxyuridine/pharmacology Dimethyl Sulfoxide/pharmacology Endoplasmic Reticulum Humans Inclusion Bodies, Viral Iodine/pharmacology Male Microscopy, Electron Middle Aged Oncogenic Viruses/growth & development Rhabdomyosarcoma/microbiology

Chemicals

Iodine Deoxyuridine Dimethyl Sulfoxide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Stewart S E

Kasnic G

Draycott C

Ben T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.175.4018.198

Published

1972-01-14

Pages

198-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.175.4018.198 View journal details

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Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide.

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