Chronic liver disease and mitochondrial antibodies: a family study.

British medical journal ·Vol. 1 ·No. 5793 ·1972-01-15 ·Pages 146-8

Walker JG, Bates D, Doniach D, Ball PA, Sherlock S

Abstract

Two sisters had primary biliary disease and associated autoimmune thyroiditis with high titres of mitochondrial and other autoantibodies. Their deceased mother possibly suffered from similar disorders. In the same family two brothers had multiple autoimmune reactions, including mitochondrial antibodies, but liver function tests gave normal results. Ten other close relatives were investigated. Australia antigen was not found in the proband or her relatives.

MeSH Terms

Adult Aged Autoantibodies/analysis Autoimmune Diseases/genetics Chronic Disease Female Hepatitis B Antigens Humans Liver Cirrhosis, Biliary/genetics,immunology Liver Function Tests Male Middle Aged Mitochondria/immunology Pedigree Sulfobromophthalein Thyroiditis/genetics

Chemicals

Autoantibodies Hepatitis B Antigens Sulfobromophthalein

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Walker J G

Bates D

Doniach D

Ball P A

Sherlock S

References (10)

10 references, click to expand

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Science. 1970 Aug 7;169(3945):593-5 PMID: 4987681
Mitochondrial antibodies and subclinical liver disease.
Q J Med. 1970 Jan;39(153):31-48 PMID: 4193516
Mitochondrial and other tissue autoantibodies in patients with biological false positive reactions for syphilis.
Clin Exp Immunol. 1970 Jun;6(6):871-84 PMID: 5312260
Familial cirrhosis with autoimmune features and raised immunoglobulin levels.
Gastroenterology. 1970 Oct;59(4):546-52 PMID: 4097813
Australia antigen in familial cirrhosis.
Lancet. 1971 Jan 30;1(7692):244 PMID: 4099909
ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
N Engl J Med. 1964 Jul 23;271:165-71 PMID: 14158353
FAMILIAL CIRRHOSIS: A CLINICAL AND PATHOLOGICAL STUDY.
Ann Intern Med. 1964 Oct;61:667-79 PMID: 14217129
HEREDITARY HYPERGAMMAGLOBULINEMIA AND LUPOID HEPATITIS.
Acta Med Scand. 1965 Jun;177:751-9 PMID: 14334668
Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications.
Clin Exp Immunol. 1966 Jul;1(3):237-62 PMID: 5330183
A genetic approach to the pathogenesis of hepatic cirrhosis. A clinical and serological study.
Acta Med Scand. 1966 May;179(5):527-33 PMID: 4160726

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5793.146

Published

1972-01-15

Pages

146-8

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1787106

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5793.146 PMC Full Text

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