Home LiteratureArticle Details
PMID: 5004427 Published · ppublish English Journal Article

Diminished antibiotic sensitivity of Neisseria gonorrhoeae in urban and rural areas in Kenya.

Bulletin of the World Health Organization ·Vol. 45 ·No. 6 ·1971-00-00 ·Pages 707-17

Verhagen AR, Van der Ham M, Heimans AL, Kranendonk O, Maina AN

Abstract

暂无摘要

Keywords
Africa Africa South Of The Sahara Antibiotics Bacterial And Fungal Diseases Data Analysis Demographic Factors Developing Countries Diseases Drugs Eastern Africa English Speaking Africa Evaluation Examinations And Diagnoses Infections Kenya Physical Examinations And Diagnoses Population Population Characteristics Reproductive Tract Infections Research Methodology Rural Population Sexually Transmitted Diseases Treatment Urban Population
MeSH Terms
Anti-Bacterial Agents/pharmacology,therapeutic use Drug Resistance, Microbial Female Gonorrhea/drug therapy Humans Kenya Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Penicillin Resistance Rural Health Urban Population
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Verhagen A R
Van der Ham M
Heimans A L
Kranendonk O
Maina A N
Other Abstracts
eng

A total of 1730 cases of suspected gonorrhea were investigated in 8 urban and rural clinics in Kenya

sensitivity tests were performed in 736 cases. A majority of the strains had relative resistance to 2 drugs in common use--penicillin and streptomycin. For tetracycline, a slightly decreased sensitivity was often found and resistance to these antibiotics was usually linked. It was found that relative resistance to antibiotics is already common in rural areas in which the majority of the African population live, and that resistance to penicillin is even more common in rural areas than towns. Evidence that this may result from the continuation of inadequate treatment, especially in developing tropical countries was obtained. Such countries are becoming an immense reservoir of strains with a high level of resistance to penicillin. Ways of remedying this situation are discussed. (author's modified)

References (42)
42 references, click to expand
  1. Gonorrhea in the obstetric and gynecologic clinic. Incidence in a voluntary hospital in an urban community.
    JAMA. 1969 Oct 13;210(2):309-11 PMID: 4980780
  2. The social determinants of gonorrhoea in an East African town.
    East Afr Med J. 1962 Jun;39:332-42 PMID: 13867299
  3. Antibiotic sensitivity of gonococcal strains isolated in the South-East Asia and Western Pacific regions in 1961-68.
    Bull World Health Organ. 1969;40(2):257-62 PMID: 4979392
  4. [Gonococcal resistance to penicillin].
    Dermatologica. 1969;139(4):254-9 PMID: 4989089
  5. Six-city study of treatment of gonorrhoea in men using single oral doses of 1.5 or 3 g. tetracycline hydrochloride.
    Br J Vener Dis. 1970 Aug;46(4):330-3 PMID: 5470081
  6. Single-dose antibiotic treatment of asymptomatic gonorrhea in hospitalized women.
    N Engl J Med. 1970 Jul 2;283(1):1-6 PMID: 4986777
  7. Problems in diagnosis, treatment and control of gonorrheal infections. II. Routine sensitivity tests with the plate dilution and disc methods.
    Acta Derm Venereol. 1965;45(3):223-30 PMID: 4163242
  8. Comparative investigations of the sensitivity of N. gonorrhoeae to penicillin.
    Acta Pathol Microbiol Scand. 1963;57:235-55 PMID: 13981907
  9. GONORRHOEA AND URETHRAL STRICTURE.
    Br J Vener Dis. 1965 Jun;41:135-6 PMID: 14332078
  10. Effects of penicillin, streptomycin, and tetracycline on N. gonorrhoeae isolated in 1944 and in 1957.
    Br J Vener Dis. 1958 Dec;34(4):227-39 PMID: 13618566
  11. Use of vancomycin, colistimethate, nystatin medium to transport gonococcal specimens.
    Public Health Rep. 1970 May;85(5):390-2 PMID: 4191775
  12. Attitudes of college students in East Africa to sexual activity and venereal disease.
    Br J Vener Dis. 1968 Jun;44(2):160-6 PMID: 5761647
  13. Antibiotic sensitivity of gonococci in Kampala.
    East Afr Med J. 1969 Jan;46(1):38-45 PMID: 4976995
  14. The problem of penicillin resistant gonococci.
    Br J Vener Dis. 1968 Dec;44(4):315-8 PMID: 4974338
  15. Comparative study of two therapies for gonorrhea.
    Public Health Rep. 1969 Nov;84(11):980-4 PMID: 4982257
  16. Venereal disease in an elite group (university students) in East Africa.
    Br J Vener Dis. 1967 Dec;43(4):275-9 PMID: 5630609
  17. Single-dose treatment of gonorrhea with selected antibiotic agents.
    JAMA. 1969 Nov 3;210(5):857-61 PMID: 4981121
  18. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined.
    Br J Vener Dis. 1969 Sep;45(3):235-7 PMID: 5346421
  19. Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968.
    Br J Vener Dis. 1969 Sep;45(3):216-22 PMID: 4981351
  20. The occurrence oNeisseria gonorrhoeae in "routine" genital cultures.
    Am J Clin Pathol. 1969 Aug;52(2):174-5 PMID: 4978977
  21. Diagnosis of vaginal discharge.
    Br J Vener Dis. 1970 Apr;46(2):122-4 PMID: 4987894
  22. Studies of venereal disease. I. Probenecid-procaine penicillin G combination and tetracycline hydrochloride in the treatment of "penicillin-resistant" gonorrhea in men.
    JAMA. 1967 Nov 6;202(6):461-73 PMID: 4963707
  23. Observations on the culture diagnosis of gonorrhea in women.
    JAMA. 1969 Oct 13;210(2):312-4 PMID: 4980781
  24. These dying diseases; venerology in decline.
    Lancet. 1958 Mar 29;1(7022):651-7 PMID: 13515312
  25. Antibiotic sensitivity of gonococci and treatment of gonorrhoea in Uganda.
    Br J Vener Dis. 1970 Apr;46(2):149-52 PMID: 4987896
  26. A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.
    Br J Vener Dis. 1970 Jun;46(3):217-42 PMID: 4246923
  27. Diagnosis and treatment of gonorrhea in the female.
    N Engl J Med. 1967 Jun 29;276(26):1454-9 PMID: 4961108
  28. Susceptibility of Neisseria gonorrhoeae to penicillin.
    Med J Aust. 1967 Apr 29;1(17):849-50 PMID: 4960816
  29. A survey of the range of sensitivity in vitro of N. gonorrhoea to penicillin.
    Indian J Med Res. 1966 Sep;54(9):823-38 PMID: 4962618
  30. Gonococcal salpingitis.
    Br J Vener Dis. 1969 Sep;45(3):205-15 PMID: 4981350
  31. Sensitivity of gonococci to antibiotics in strains isolated from "prostitutes" in Copenhagen.
    Br J Vener Dis. 1970 Apr;46(2):153-5 PMID: 4987897
  32. Identification of the asymptomatic female carrier of N. gonorrhoeae. Treatment with ampicillin.
    Br J Vener Dis. 1970 Aug;46(4):334-5 PMID: 4990376
  33. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment.
    Br J Vener Dis. 1958 Jun;34(2):70-8; discussion 78-82 PMID: 13560791
  34. HIGH DOSES OF PENICILLIN IN THE TREATMENT OF GONORRHOEA: RESULTS OF TREATMENT CORRELATED WITH THE SENSITIVITY PATTERNS OF THE CAUSATIVE GONOCOCCAL STRAINS.
    Br J Vener Dis. 1964 Dec;40:273-7 PMID: 14243827
  35. Incidence of bacterial causes of ophthalmia neonatorum.
    East Afr Med J. 1970 Mar;47(3):159-62 PMID: 5422957
  36. Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis.
    Public Health Rep. 1966 Jun;81(6):559-62 PMID: 4957043
  37. Gonococcal urethritis in males in Vietnam: three penicillin regimens and one tetracycline regimen.
    JAMA. 1969 Feb 3;207(5):946-8 PMID: 4974349
  38. Failure to control gonorrhoea.
    Bull World Health Organ. 1961;24:297-306 PMID: 13709981
  39. Gonorrhoea treated by a combination of probenecid and sodium penicillin G.
    Br J Vener Dis. 1969 Jun;45(2):144-8 PMID: 5787685
  40. Problems in diagnosis, treatment and control of gonorrheal infections. IV. The correlation between the dose of penicillin, concentration in blood, IC-50-values of gonococci and results of treatment.
    Acta Derm Venereol. 1965;45(3):242-53 PMID: 4163244
  41. GONOCOCCAL URETHRAL STRICTURE AND HYPERTENSION. EXPERIENCE IN UGANDA.
    Br J Vener Dis. 1964 Sep;40:194-5 PMID: 14210486
  42. Sensitivity of strains of gonococci to penicillin, sulphathiazole, and streptomycin.
    Br Med J. 1958 May 10;1(5079):1091-2 PMID: 13536426
Article Info
Journal
Bulletin of the World Health Organization
Abbr.
Bull World Health Organ
ISSN
0042-9686
Published
1971-00-00
Pages
707-17
Language
English
Region
Switzerland
NLM ID
7507052
PMCID
PMC2427988
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2