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PMID: 5002818 Published · ppublish English Journal Article

Production of albumin and other serum proteins by clonal cultures of normal human liver.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 10 ·1971-10-00 ·Pages 2396-400

Kaighn ME, Prince AM

Abstract

Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.

MeSH Terms
Adult Age Factors Blood Proteins/analysis,biosynthesis Carbon Isotopes Cell Division Clone Cells/cytology,metabolism Complement System Proteins/biosynthesis Epithelial Cells Fetus/cytology Fibrinogen/biosynthesis Fibroblasts Glycoproteins/biosynthesis Haptoglobins/biosynthesis Humans Immunodiffusion Immunoelectrophoresis Infant Lipoproteins/biosynthesis Liver/cytology,metabolism Macroglobulins/biosynthesis Radioimmunoassay Serum Albumin/biosynthesis Transferrin/biosynthesis
Chemicals
Blood Proteins Carbon Isotopes Glycoproteins Haptoglobins Lipoproteins Macroglobulins Serum Albumin Transferrin Fibrinogen Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kaighn M E
Prince A M
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.68.10.2396
Published
1971-10-00
Pages
2396-400
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389430
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.68.10.2396 PMC Full Text View journal details
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