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PMID: 4994446 Published · ppublish English Journal Article

Host defense against bacterial endotoxemia: mechanism in normal animals.

The Journal of experimental medicine ·Vol. 132 ·No. 2 ·1970-08-01 ·Pages 300-16

Skarnes RC

Abstract

The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxifying capacity. These results are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.

MeSH Terms
Animals Antigens/analysis Autoradiography Biological Assay Biotransformation Blood Protein Electrophoresis Calcium/blood Chromium Isotopes Endotoxins Escherichia coli Esterases/blood Immunodiffusion Injections, Intravenous Rabbits Salmonella Toxemia/blood,physiopathology
Chemicals
Antigens Chromium Isotopes Endotoxins Esterases Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Skarnes R C
References (24)
24 references, click to expand
  1. Inactivation of endotoxin by a humoral component. II. Interaction of endotoxin with serum and plasma.
    J Exp Med. 1958 Nov 1;108(5):685-99 PMID: 13587851
  2. The Limulus coagulation test for endotoxin. A comparison with other assay methods.
    Proc Soc Exp Biol Med. 1969 Nov;132(2):599-601 PMID: 5355111
  3. Localization and fate of 51-Cr-labeled somatic antigens of smooth and rough Salmonellae.
    Ann N Y Acad Sci. 1966 Jun 30;133(2):712-26 PMID: 4960349
  4. The alteration of endotoxin by postheparin plasma and purified fractions. II. Relationship of the endotoxin detoxifying activity of euglobulin from postheparin plasma to lipoprotein lipase.
    J Immunol. 1967 Mar;98(3):482-9 PMID: 5335974
  5. RESTORATION OF ENDOTOXIN ACTIVITY FOLLOWING ALTERATION BY PLASMA.
    Nature. 1964 May 23;202:811-2 PMID: 14187634
  6. Investigations on the mechanism of stimulation of non-specific immunity by bacterial lipopolysaccharides.
    Immunology. 1958 Jul;1(3):181-203 PMID: 13574824
  7. The inactivation of endotoxin after interaction with certain proteins of normal serum.
    Ann N Y Acad Sci. 1966 Jun 30;133(2):644-62 PMID: 4164246
  8. The essential role of the liver in detoxification of endotoxin.
    Ann N Y Acad Sci. 1966 Jun 30;133(2):668-84 PMID: 5336354
  9. Effect of endotoxin on simultaneously determined cardiac output and hepatic blood flow in rabbits.
    J Lab Clin Med. 1963 Mar;61:483-93 PMID: 13936145
  10. Fractionation of an esterase from calf spleen implicated in the detoxification of bacterial endotoxin.
    Proc Soc Exp Biol Med. 1968 May;128(1):75-80 PMID: 4297823
  11. Detoxification of endotoxin by perfusion of liver and spleen.
    Proc Soc Exp Biol Med. 1967 Jun;125(2):455-9 PMID: 6028564
  12. Sensitivity of mice to bacterial lipopolysaccharide following alteration of activity of the reticulo-endothelial system.
    Nature. 1961 Jul 15;191:294-5 PMID: 13695315
  13. Effect of bacterial endotoxins on the reticuloendothelial system.
    Fed Proc. 1957 Sep;16(3):860-7 PMID: 13480376
  14. Characterization of a Cr51-labeled endotoxin and its identification in plasma and urine after parenteral administration.
    J Exp Med. 1963 Apr 1;117:561-71 PMID: 14020462
  15. NATURE OF THE ENDOTOXIN-INACTIVATING PRINCIPLE IN GUINEA-PIG LIVER.
    J Bacteriol. 1964 Apr;87:832-7 PMID: 14137621
  16. Serum lipids in infection.
    N Engl J Med. 1969 Nov 13;281(20):1081-6 PMID: 5824173
  17. DENERVATION OF THE ABDOMINAL VISCERA FOR THE TREATMENT OF TRAUMATIC SHOCK.
    N Engl J Med. 1963 Oct 3;269:709-16 PMID: 14050976
  18. In vivo detoxification of endotoxin by the reticuloendothelial system.
    J Exp Med. 1960 Dec 1;112:1157-66 PMID: 13786140
  19. Pathogenesis of fever.
    Physiol Rev. 1960 Jul;40:580-646 PMID: 13794961
  20. In vivo interaction of endotoxin with a plasma lipoprotein having esterase activity.
    J Bacteriol. 1968 Jun;95(6):2031-4 PMID: 4970220
  21. Reversible inactivation of an endotoxin by plasma proteins.
    Ann N Y Acad Sci. 1966 Jun 30;133(2):622-8 PMID: 4164245
  22. The effects of bacterial endotoxin on lipide metabolism. I. The responses of the serum lipides of rabbits to single and repeated injections of Shear's polysaccharide.
    J Exp Med. 1959 Aug 1;110(2):293-309 PMID: 13673140
  23. HYPERLIPIDEMIA, FATTY LIVER, AND BROMSULFOPHTHALEIN RETENTION IN RABBITS INJECTED INTRAVENOUSLY WITH BACTERIAL ENDOTOXINS.
    J Lipid Res. 1964 Oct;5:563-8 PMID: 14221101
  24. Inactivation of endotoxin by a humoral component. III. Role of divalent cation and a dialyzable component.
    J Exp Med. 1958 Nov 1;108(5):701-11 PMID: 13587852
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.132.2.300
Published
1970-08-01
Pages
300-16
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138734
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.132.2.300 PMC Full Text View journal details
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