Reversible inhibition in bimolecular rapid equilibrium random order enzyme systems. The effect of substrate-substrate and inhibitor-substrate interactions.

The Biochemical journal ·Vol. 117 ·No. 5 ·1970-05-00 ·Pages 997-1003

Clark AG

Abstract

A model is presented that accounts for all types of reversible inhibition by a single inhibitor molecule in bimolecular rapid-equilibrium random-order enzyme systems. The characterization of inhibition mechanisms by graphical methods is examined, and a system of nomenclature is suggested.

MeSH Terms

Enzyme Inhibitors Kinetics Models, Biological

Chemicals

Enzyme Inhibitors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Clark A G

References (9)

9 references, click to expand

Comparative detoxication. 10. The enzymic conjugation of chloro compounds with glutathione in locusts and other insects.
Biochem J. 1964 Mar;90(3):457-64 PMID: 5833356
Species differences in the inhibition of glutathione S-aryltransferase by phthaleins and dicarboxylic acids.
Biochem J. 1967 Apr;103(1):49-54 PMID: 6033774
Enzymes catalysing conjugations of glutathione with alpha-beta-unsaturated carbonyl compounds.
Biochem J. 1968 Oct;109(4):651-61 PMID: 5683512
The inhibition of 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) dehydrochlorinase and glutathione S-aryltransferase in grass-grub and housefly preparations.
Biochem J. 1970 May;117(5):989-96 PMID: 5451919
The determination of enzyme inhibitor constants.
Biochem J. 1953 Aug;55(1):170-1 PMID: 13093635
Graphical analysis of single enzyme systems.
Enzymologia. 1956 Jul 15;17(5-6):273-8 PMID: 13397508
Graphical determination of the dissociation constants for two-substrate enzyme systems.
Biochim Biophys Acta. 1957 Sep;25(3):575-8 PMID: 13479429
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory.
Biochim Biophys Acta. 1963 Feb 12;67:173-87 PMID: 14021668
TREATMENT OF ENZYME KINETIC DATA. I. THE EFFECT OF MODIFIERS ON THE KINETIC PARAMETERS OF SINGLE SUBSTRATE ENZYMERS.
J Biol Chem. 1964 Oct;239:3522-31 PMID: 14245413

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1170997

Published

1970-05-00

Pages

997-1003

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1179061

Subset

External Links

PubMed source DOI: 10.1042/bj1170997 PMC Full Text View journal details

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Reversible inhibition in bimolecular rapid equilibrium random order enzyme systems. The effect of substrate-substrate and inhibitor-substrate interactions.

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