Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.

Science (New York, N.Y.) ·Vol. 169 ·No. 3942 ·1970-07-17 ·Pages 289-90

Fitch CD

Abstract

Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 10(7) liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.

MeSH Terms

Animals Carbon Isotopes Chloroquine/blood,therapeutic use Disease Models, Animal Drug Resistance, Microbial Erythrocytes/microbiology Haplorhini Malaria/blood,drug therapy Monkey Diseases Plasmodium falciparum Receptors, Drug Species Specificity

Chemicals

Carbon Isotopes Receptors, Drug Chloroquine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Fitch C D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.169.3942.289

Published

1970-07-17

Pages

289-90

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.169.3942.289 View journal details

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Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.

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