Induction of brain D(--)-beta-hydroxybytrate dehydrogenase activity by fasting.

Science (New York, N.Y.) ·Vol. 163 ·No. 3862 ·1969-01-03 ·Pages 79-81

Smith AL, Satterthwaite HS, Sokoloff L

Abstract

D(m)-beta-hydroxybutyrate dehydrogenase activity is very low in normal adult rat brain; but during fasting it increases severalfold in parallel with the ketosis. The increase may represent part of a mechanism by which the brain adapts to changing patterns of substrate supply during starvation.

MeSH Terms

Acetoacetates/blood Acidosis Animals Body Weight Brain/cytology,enzymology Edetic Acid Enzyme Induction Fasting Hydroxybutyrate Dehydrogenase/biosynthesis Hydroxybutyrates/blood Male Mitochondria/enzymology Organ Size Phosphatidylcholines/metabolism Rats

Chemicals

Acetoacetates Hydroxybutyrates Phosphatidylcholines Edetic Acid Hydroxybutyrate Dehydrogenase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Smith A L

Satterthwaite H S

Sokoloff L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.163.3862.79

Published

1969-01-03

Pages

79-81

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.163.3862.79 View journal details

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Induction of brain D(--)-beta-hydroxybytrate dehydrogenase activity by fasting.

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