Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.

Alkaloids/pharmacology Animals Anti-Bacterial Agents/pharmacology Carbon Isotopes Cell Nucleus/enzymology Centrifugation, Density Gradient Chromatography, Thin Layer DNA Nucleotidyltransferases DNA, Neoplasm/biosynthesis Escherichia coli/enzymology HeLa Cells/metabolism Leucine/metabolism Metabolism/drug effects Neoplasm Proteins/biosynthesis Nucleic Acids/biosynthesis RNA Nucleotidyltransferases RNA, Neoplasm/biosynthesis RNA, Ribosomal/biosynthesis Rabbits Reticulocytes/drug effects Structure-Activity Relationship Thymidine/metabolism Tritium Uridine/metabolism

Alkaloids Anti-Bacterial Agents Carbon Isotopes DNA, Neoplasm Neoplasm Proteins Nucleic Acids RNA, Neoplasm RNA, Ribosomal Tritium DNA Nucleotidyltransferases RNA Nucleotidyltransferases Leucine Thymidine Uridine