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PMID: 4927813 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Controlled trial of metoclopramide in the treatment of flatulent dyspepsia.

British medical journal ·Vol. 2 ·No. 5752 ·1971-04-03 ·Pages 25-6

Johnson AG

Abstract

A double-blind cross-over trial of metoclopramide (Maxolon) against placebo was undertaken in 42 patients with flatulent dyspepsia. A highly significant difference was found in favour of the active drug (P<0.01). The time at which the drug is given in relation to the meal and onset of symptoms is probably important. It is concluded that metoclopramide is effective in the short-term treatment of these symptoms but should be started only after thorough investigations have excluded more serious disease.

MeSH Terms
Adolescent Adult Aged Amides/therapeutic use Barium Sulfate Benzoates/therapeutic use Cholecystectomy/adverse effects Cholecystography Clinical Trials as Topic Diagnosis, Differential Dyspepsia/diagnosis,drug therapy Female Flatulence/diagnosis,drug therapy Humans Male Middle Aged Vagotomy/adverse effects
Chemicals
Amides Benzoates Barium Sulfate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Johnson A G
References (11)
11 references, click to expand
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  7. The use of oral Metoclopramide in the barium meal and follow-through examination.
    Br J Radiol. 1970 Jan;43(505):31-5 PMID: 4983588
  8. A double-blind trial of metoclopramide and prochlorperazine in general practice.
    Br J Clin Pract. 1970 Jan;24(1):25-7 PMID: 4905141
  9. The effect of metoclopramide on gastroduodenal and gallbladder contractions.
    Gut. 1971 Feb;12(2):158-63 PMID: 5548563
  10. Gall-bladder dyspepsia.
    Br Med J. 1963 Jul 20;2(5350):138-41 PMID: 13986155
  11. LATE RESULTS FOLLOWING CHOLECYSTECTOMY IN 1930 CASES AND SPECIAL STUDIES ON POSTOPERATIVE BILIARY DISTRESS.
    Acta Chir Scand Suppl. 1964;325:SUPPL 329:1+ PMID: 14127250
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.2.5752.25
Published
1971-04-03
Pages
25-6
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1795898
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.2.5752.25 PMC Full Text
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