L-asparaginase and human malignant disease.

Animals Antineoplastic Agents/therapeutic use Asparaginase/adverse effects,blood,therapeutic use Blood Coagulation/drug effects Central Nervous System/drug effects Drug Hypersensitivity Drug Synergism Escherichia coli/enzymology Fever/chemically induced Humans Hyperglycemia/chemically induced In Vitro Techniques Leukemia, Lymphoid/drug therapy Leukemia, Myeloid, Acute/drug therapy Ligases/analysis Lymphocyte Activation/drug effects Lymphoma, Non-Hodgkin/drug therapy Molecular Weight Prednisone/therapeutic use Sarcoma, Experimental/metabolism Stereoisomerism Tritium Uridine/metabolism Valine/metabolism Vincristine/therapeutic use Vomiting/chemically induced

Antineoplastic Agents Tritium Vincristine Asparaginase Ligases Valine Prednisone Uridine