Release of nuclear DNA template restrictions by specific polyribonucleotides.

Science (New York, N.Y.) ·Vol. 171 ·No. 3967 ·1971-01-15 ·Pages 176-8

Brown DG, Offey DS

Abstract

Certain synthetic homo- and copolyribonucleotide polymers are capable of releasing the DNA template restriction of isolated nuclei of rat liver cells when assayed with an excess of or in the absence of exogenous DNA polymerase. The purine homopolyribonucleotides are far more effective than are the pyrimidine polymers.

MeSH Terms

Adenine Nucleotides/pharmacology Animals Cell Nucleus/metabolism Cytosine Nucleotides/pharmacology DNA/metabolism DNA Nucleotidyltransferases/metabolism DNA, Bacterial/biosynthesis Depression, Chemical Escherichia coli/enzymology Guanine Nucleotides/pharmacology Hot Temperature Liver/cytology,metabolism Nucleic Acid Denaturation Polynucleotides/pharmacology RNA, Messenger/biosynthesis Rats Stimulation, Chemical Templates, Genetic Thymus Gland Uracil Nucleotides/pharmacology

Chemicals

Adenine Nucleotides Cytosine Nucleotides DNA, Bacterial Guanine Nucleotides Polynucleotides RNA, Messenger Uracil Nucleotides DNA DNA Nucleotidyltransferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brown D G

Offey D S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.171.3967.176

Published

1971-01-15

Pages

176-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.171.3967.176 View journal details

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Release of nuclear DNA template restrictions by specific polyribonucleotides.

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