Kasugamycin resistance: 30S ribosomal mutation with an unusual location on the Escherichia coli chromosome.

Science (New York, N.Y.) ·Vol. 167 ·No. 3914 ·1970-01-02 ·Pages 56-8

Sparling PF

Abstract

A mutation in Escherichia coli to resistance to the aminoglycoside antibiotic kasugamycin alters the 30S ribosomal subunit. Though all other known 30S ribosomal mutations are located in a cluster in the streptomycin region, kasugamycin resistance is located at a distance from this region, near the leucine region.

MeSH Terms

Anti-Bacterial Agents/pharmacology Carbon Isotopes Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Escherichia coli Mutation Phenylalanine/metabolism Ribosomes Valine/metabolism

Chemicals

Anti-Bacterial Agents Carbon Isotopes Phenylalanine Valine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sparling P F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.167.3914.56

Published

1970-01-02

Pages

56-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.167.3914.56 View journal details

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Kasugamycin resistance: 30S ribosomal mutation with an unusual location on the Escherichia coli chromosome.

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