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PMID: 489132 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Liposomal enhancement of the immunogenicity of adenovirus type 5 hexon and fiber vaccines.

Infection and immunity ·Vol. 25 ·No. 2 ·1979-08-00 ·Pages 771-3

Kramp WJ, Six HR, Drake S, Kasel JA

Abstract

Immunogenicity of adenovirus capsid proteins carried in liposomes was comparable to that with equivalent doses administered in Freund adjuvant, and both forms were more potent than aqueous vaccines.

MeSH Terms

Adenoviruses, Human/immunology Animals Antibody Formation Antigens, Viral Immunologic Memory Injections, Intramuscular Liposomes Rabbits Viral Proteins/immunology Viral Vaccines/immunology

Chemicals

Antigens, Viral Liposomes Viral Proteins Viral Vaccines

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kramp W J

Six H R

Drake S

Kasel J A

References (17)

17 references, click to expand

IMMUNIZATION OF VOLUNTEERS WITH SOLUBLE ANTIGENS OF ADENOVIRUS TYPE 1.
Proc Soc Exp Biol Med. 1964 Oct;117:186-90 PMID: 14219941
PRODUCTION OF SPECIFIC NEUTRALIZING ANTIBODY WITH SOLUBLE ANTIGENS OF TYPE 5 ADENOVIRUS.
Proc Soc Exp Biol Med. 1963 Oct;114:37-42 PMID: 14076907
Immunogenicity of liposomal model membranes.
Ann N Y Acad Sci. 1978;308:111-23 PMID: 279284
Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant.
Science. 1978 Sep 29;201(4362):1237-9 PMID: 99814
Liposome toxicity in the mouse central nervous system.
J Neurol Sci. 1977 Mar;31(2):173-9 PMID: 839231
The adjuvant properties of liposomes.
Biochem Soc Trans. 1976;4(1):129-33 PMID: 1001617
Release of macromolecular markers (enzymes) from liposomes treated with antibody and complement. An attempt at correlation with electron microscopic observations.
Biochim Biophys Acta. 1973 Mar 16;298(2):158-79 PMID: 4737015
Preparation of liposomes and a spectrophotometric assay for release of trapped glucose marker.
Methods Enzymol. 1974;32:501-13 PMID: 4444535
Effect of antibody-complement on multiple vs. single compartment liposomes. Application of a fluorometric assay for following changes in liposomal permeability.
Biochemistry. 1974 Sep 10;13(19):4050-8 PMID: 4213052
Liposomes as immunological adjuvants.
Nature. 1974 Nov 15;252(5480):252 PMID: 4424229
The purification of adenovirus neutralizing antibody: adenovirus type 5 hexon immunoadsorbent.
J Immunol. 1972 Mar;108(3):633-6 PMID: 4110983
Induction of immunity in man by crystalline adenovirus type 5 capsid antigens.
Proc Soc Exp Biol Med. 1973 Sep;143(4):905-10 PMID: 4355246
Antigenic determinants of adenovirus capsids. I. Measurement of antibody cross-reactivity.
J Immunol. 1976 Jan;116(1):19-24 PMID: 54385
Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.
Science. 1972 Nov 24;178(4063):871-2 PMID: 5085985
Crystallization of a second adenovirus protein (the fibre).
Nature. 1971 Apr 16;230(5294):456-7 PMID: 4995710
Crystallization of an adenovirus protein (the hexon).
Nature. 1968 Aug 31;219(5157):946-7 PMID: 4970539
Incorporation of lysozyme into liposomes. A model for structure-linked latency.
J Biol Chem. 1970 Jul 10;245(13):3295-301 PMID: 5459633

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.25.2.771-773.1979

Published

1979-08-00

Pages

771-3

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414511

Subset

External Links

PubMed source DOI: 10.1128/iai.25.2.771-773.1979 PMC Full Text View journal details

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Liposomal enhancement of the immunogenicity of adenovirus type 5 hexon and fiber vaccines.

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