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PMID: 488566 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes.

Diabetologia ·Vol. 17 ·No. 2 ·1979-08-00 ·Pages 111-6

Kobayashi M, Olefsky JM

Abstract

Glucose oxidation and lipogenesis were studied in isolated adipocytes from control and non-obese, experimentally hyperinsulinaemic rats. In cells from the hyperinsulinaemic animals oxidation of either [1(-14) C]- or [6(-14) C] glucose was increased in the presence or absence of insulin, at substrate concentrations from 0.1 to 20 mmol/l. Glucose incorporation into total triglycerides and fatty acids was also increased. These enhanced rates of glucose metabolism were due to increased activity of the glucose transport system in addition to increased activity of intracellular glucose metabolism. Therefore, these data indicate that insulin can influence long term glucose homoeostasis by augmenting the overall cellular capacity for glucose metabolism at several loci.

MeSH Terms
Adipose Tissue/drug effects,metabolism Animals Fatty Acids/biosynthesis Glucose/metabolism Glycerides/biosynthesis Glycolysis/drug effects In Vitro Techniques Insulin/pharmacology Kinetics Lipids/biosynthesis Male Rats
Chemicals
Fatty Acids Glycerides Insulin Lipids Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kobayashi M
Olefsky J M
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30 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF01222211
Published
1979-08-00
Pages
111-6
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01222211 View journal details
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