Mutant Sl alleles of mice affect susceptibility to Friend spleen focus-forming virus.

Science (New York, N.Y.) ·Vol. 162 ·No. 3853 ·1968-11-01 ·Pages 564-5

Bennett M, Steeves RA, Cudkowicz G, Mirand EA, Russell LB

Abstract

Mice of genotypes S1/S1(d), S1/+, and S1(d)/+ (but not S1(T)/S1(T) or S1(T)/+) were resistant to spleen focucs-forming virus. The "environment" in which hemopoietic target cells for this virus develop was not conducive for infection or focus formation, or both, but the target cells were not altered directly. The same genes appear to regulate hemopoiesis and leukemogenic transformation.

MeSH Terms

Alleles Animals Bone Marrow Transplantation Cell Transformation, Neoplastic Female Friend murine leukemia virus/pathogenicity Genotype Hematocrit Hematopoiesis Leukemia, Experimental/etiology Male Mice Mutation Spleen/microbiology

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bennett M

Steeves R A

Cudkowicz G

Mirand E A

Russell L B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3853.564

Published

1968-11-01

Pages

564-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3853.564 View journal details

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Mutant Sl alleles of mice affect susceptibility to Friend spleen focus-forming virus.

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