Human C'3: evidence for the liver as the primary site of synthesis.

Science (New York, N.Y.) ·Vol. 163 ·No. 3864 ·1969-01-17 ·Pages 286-8

Alper CA, Johnson AM, Birtch AG, Moore FD

Abstract

The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C'3 FS(0.6) to C'3 SS, the donor type, following homotransplantation of the liver.

MeSH Terms

Adolescent Antilymphocyte Serum/pharmacology Azathioprine/pharmacology Blood Protein Electrophoresis Child Complement System Proteins/biosynthesis Haptoglobins/analysis Humans Liver/immunology,metabolism Liver Transplantation Male Molecular Biology Polymorphism, Genetic Prednisone/pharmacology Transplantation Immunology Transplantation, Homologous

Chemicals

Antilymphocyte Serum Haptoglobins Complement System Proteins Azathioprine Prednisone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Alper C A

Johnson A M

Birtch A G

Moore F D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.163.3864.286

Published

1969-01-17

Pages

286-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.163.3864.286 View journal details

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Human C'3: evidence for the liver as the primary site of synthesis.

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