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PMID: 4879569 Published · ppublish English Journal Article

Selection of a mutant of Escherichia coli which has high mutation rates.

Journal of bacteriology ·Vol. 96 ·No. 4 ·1968-10-00 ·Pages 975-80

Helling RB

Abstract

A mutation which causes high mutation rates in all other loci tested was induced with nitrosoguanidine and was selected through the ability of the progeny of such mutant cells to mutate to streptomycin resistance at a higher rate than the wild-type cells. This mutation (mut-2) and the Treffers' mutation (mutT1) mapped at approximately the same position to the right of leu. Specificity studies showed that the two mutations differ in rates of mutation produced.

MeSH Terms
Crosses, Genetic Drug Resistance, Microbial Escherichia coli/drug effects Genetics, Microbial Lysogeny Mutagens/pharmacology Mutation Nitroso Compounds/pharmacology Selection, Genetic Streptomycin/pharmacology Transduction, Genetic
Chemicals
Mutagens Nitroso Compounds Streptomycin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Helling R B
References (27)
27 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.96.4.975-980.1968
Published
1968-10-00
Pages
975-80
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC252407
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.96.4.975-980.1968 PMC Full Text View journal details
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