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PMID: 4878822 Published · ppublish English Journal Article

Chromosomes and transformation of lymphocytes in lymphoproliferative disorders.

British medical journal ·Vol. 4 ·No. 5625 ·1968-10-26 ·Pages 213-9

Lawler SD, Pentycross CR, Reeves BR

Abstract

In chronic lymphocytic leukaemia the majority of circulating lymphocytes which responded to phytohaemagglutinin in vitro were found to have normal karyotypes. A minor population of cells in patients treated with chemotherapy had an increased number of chromosomal rearrangements as compared with cells from normal controls and untreated patients with chronic lymphocytic leukaemia. Probably bonemarrow and lymph-node cells also had a normal karyotype.In the other lymphoproliferative disorders the peripheral blood lymphocytes had either normal karyotypes or chromosomal abnormalities attributable to treatment, even in those cases where the tumour cells of involved lymph nodes were known to have abnormal karyotypes.It was possible that circulating tumour cells were present in one case.

MeSH Terms
Aneuploidy/drug effects Antineoplastic Agents/adverse effects Biopsy Bone Marrow/pathology Bone Marrow Cells Chromosome Aberrations/blood,chemically induced Chromosome Disorders Humans In Vitro Techniques Karyotyping Lectins/pharmacology Leukemia, Lymphoid/complications,genetics Lymph Nodes/anatomy & histology,pathology Lymphocytes/pathology Lymphoma/pathology Lymphoma, Large B-Cell, Diffuse/pathology
Chemicals
Antineoplastic Agents Lectins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lawler S D
Pentycross C R
Reeves B R
References (22)
22 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.4.5625.213
Published
1968-10-26
Pages
213-9
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1912183
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.4.5625.213 PMC Full Text
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