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PMID: 4875806 Published · ppublish English Journal Article

Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis.

Luzzatto L, Apirion D, Schlessinger D

Abstract

暂无摘要

MeSH Terms
Bacterial Proteins/biosynthesis Drug Resistance, Microbial Escherichia coli/drug effects,metabolism RNA, Messenger/metabolism Ribosomes/drug effects,metabolism Streptomycin/pharmacology
Chemicals
Bacterial Proteins RNA, Messenger Streptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Luzzatto L
Apirion D
Schlessinger D
References (22)
22 references, click to expand
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  2. The role of the native subribosomal particles of Escherichia coli in polypeptide chain initiation.
    Proc Natl Acad Sci U S A. 1967 Oct;58(4):1560-5 PMID: 4867664
  3. Studies on polynucleotides, LXXXIV. On the role of ribosomal subunits in protein synthesis.
    Proc Natl Acad Sci U S A. 1967 Dec;58(6):2455-61 PMID: 4873591
  4. PHAGE f2 RNA-DIRECTED BINDING OF FORMYLMETHIONYL-TRNA TO RIBOSOMES AND THE ROLE OF 30S RIBOSOMAL SUBUNITS IN INITIATION OF PROTEIN SYNTHESIS.
    Proc Natl Acad Sci U S A. 1967 Sep;58(3):946-53 PMID: 16578681
  5. STREPTOMYCIN-INDUCED OVERSUPPRESSION IN E. COLI.
    Proc Natl Acad Sci U S A. 1964 Jun;51:995-1001 PMID: 14215657
  6. Cyclic dissociation into stable subunits and re-formation of ribosomes during bacterial growth.
    J Mol Biol. 1968 Jan 28;31(2):277-89 PMID: 4865485
  7. Studies on the heterogeneity of messenger RNA from E. Coli.
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  8. AMINO ACID INCORPORATION INTO PROTEINS BY ESCHERICHIA COLI RIBOSOMES.
    Proc Natl Acad Sci U S A. 1960 Nov;46(11):1450-63 PMID: 16590771
  9. Electrometric and spectrophotometric titration of histone and deoxyribonucleohistone.
    J Mol Biol. 1965 Dec;14(2):381-98 PMID: 5880857
  10. Mechanism of streptomycin action on bacteria: a unitary hypothesis.
    Nature. 1961 Nov 18;192:633-7 PMID: 13915908
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  12. Misreading of RNA codewords induced by aminoglycoside antibiotics.
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  13. Selection of sucrose-dependent Escherichia coli to obtain envelope mutants and fragile cultures.
    Science. 1966 Aug 19;153(3738):892-4 PMID: 5330706
  14. The formation and stabilization of 30S and 50S ribosome couples in Escherichia coli.
    Proc Natl Acad Sci U S A. 1967 Oct;58(4):1782-9 PMID: 4867673
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    Proc Natl Acad Sci U S A. 1964 May;51:883-90 PMID: 14173007
  16. PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI.
    Proc Natl Acad Sci U S A. 1964 Mar;51:487-93 PMID: 14171463
  17. Biosynthetic precursors of 30S and 50S ribosomal particles in Escherichia coli.
    Biochemistry. 1968 Jan;7(1):456-72 PMID: 4991482
  18. Polyribosome metabolism in Escherichia coli. I. Extraction of polyribosomes and ribosomal subunits from fragile, growing Escherichia coli.
    J Mol Biol. 1966 Sep;20(1):123-43 PMID: 5339327
  19. STREPTOMYCIN ACTION AND THE RIBOSOME.
    Proc Natl Acad Sci U S A. 1964 Apr;51:703-9 PMID: 14166778
  20. A mutation suppressing streptomycin dependence. I. An effect on ribosome function.
    J Mol Biol. 1967 Apr 14;25(1):99-109 PMID: 5340532
  21. Initiation of E. coli proteins.
    Proc Natl Acad Sci U S A. 1966 Jun;55(6):1517-24 PMID: 5336288
  22. Translation of the genetic message. VI. The role of ribosomal subunits in binding of formylmethionyl-tRNA and its reaction with puromycin.
    Proc Natl Acad Sci U S A. 1967 Oct;58(4):1652-4 PMID: 4867669
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1968-07-00
Pages
873-80
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC225133
Subset
IM
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