The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.

The Journal of experimental medicine ·Vol. 128 ·No. 1 ·1968-07-01 ·Pages 111-9

Agnew HD

Abstract

Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal.

MeSH Terms

Animals Antibodies/analysis Fluorescent Antibody Technique Hypersensitivity, Delayed/immunology Immune Sera/pharmacology Injections, Subcutaneous Leukocyte Count Leukopenia/immunology Lymph Nodes/cytology Lymphocytes/immunology Male Rabbits Rats Spleen/cytology Thoracic Duct/cytology Transplantation Immunology

Chemicals

Antibodies Immune Sera

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Agnew H D

References (14)

14 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.128.1.111

Published

1968-07-01

Pages

111-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138510

Subset

External Links

PubMed source DOI: 10.1084/jem.128.1.111 PMC Full Text View journal details

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The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.

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