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PMID: 4868581 Published · ppublish English Journal Article

Immunopathology of lymphocytic choriomeningitis viurs infection of newborn mice. Antithymocyte serum effects on glomerulonephritis and wasting disease.

The Journal of experimental medicine ·Vol. 127 ·No. 4 ·1968-04-01 ·Pages 757-66

Hirsch MS, Murphy FA, Hicklin MD

Abstract

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.

MeSH Terms
Animals Animals, Newborn Brain/pathology Complement Fixation Tests Female Fluorescent Antibody Technique Glomerulonephritis/etiology Graft vs Host Disease/etiology Immune Sera Kidney/pathology Liver/pathology Lung/pathology Lymphocytic Choriomeningitis/immunology,isolation & purification,pathology Male Musculoskeletal System/pathology Pancreas/pathology Rabbits Rats Thymus Gland/immunology
Chemicals
Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hirsch M S
Murphy F A
Hicklin M D
References (21)
21 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.127.4.757
Published
1968-04-01
Pages
757-66
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138472
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.127.4.757 PMC Full Text View journal details
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