Chloride spike: a third type of action potential in tissue-cultured skeletal muscle cells from the chick.

Science (New York, N.Y.) ·Vol. 185 ·No. 4145 ·1974-07-05 ·Pages 76-8

Fukuda J

Abstract

In addition to sodium and calcium spikes, tissue-cultured skeletal muscle cells from the chick can initiate spikes lasting tens of seconds. The peak membrane potential of the spike correlates with the chloride ion concentration, but not with the calcium or sodium ion concentration. The chloride spike is blocked by manganese ion but not by cobalt ion.

MeSH Terms

Action Potentials/drug effects Animals Calcium/pharmacology Cell Membrane/drug effects Cells, Cultured Chlorides/pharmacology Cobalt/pharmacology Culture Media Culture Techniques Electric Stimulation Manganese/pharmacology Membrane Potentials/drug effects Microelectrodes Muscles/drug effects,embryology Osmolar Concentration Sodium/pharmacology

Chemicals

Chlorides Culture Media Cobalt Manganese Sodium Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Fukuda J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.185.4145.76

Published

1974-07-05

Pages

76-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.185.4145.76 View journal details

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Chloride spike: a third type of action potential in tissue-cultured skeletal muscle cells from the chick.

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