Immunologic implications of vasectomy. II. Serum-mediated immunity.

Fertility and sterility ·Vol. 25 ·No. 6 ·1974-06-00 ·Pages 515-20

Brannen GE, Coffey DS

Abstract

暂无摘要

Keywords

Animals Laboratory Antibodies Biology Clinical Research Comparative Studies Cytologic Effects Examinations And Diagnoses Family Planning Genitalia Germ Cells Immunity Immunologic Factors Immunological Effects Laboratory Examinations And Diagnoses Laboratory Procedures Male Sterilization Physiology Research Methodology Spermatozoa Sterilization Sexual Studies Urogenital System Vas Ligation Vasectomy--side effects

MeSH Terms

Animals Chromium Radioisotopes Granuloma/etiology Immune Sera Immunity Immunoassay Ligation Male Rats Rats, Inbred Strains Spermatozoa/immunology Spleen/immunology Testis/immunology Vas Deferens/surgery Vasectomy/adverse effects

Chemicals

Chromium Radioisotopes Immune Sera

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brannen G E

Coffey D S

Other Abstracts

eng

30 male rats in groups of 10 underwent standard vasectomy with ligation of the vas deferens

vasectomy without ligation of the vas deferens (permitting intraperitoneal drainage of the open vas deferens)

or sham vasectomy. Assays (in vivo and in vitro) for serum-mediated immunity to syngeneic spermatozoa were performed with each experimental group 90 days postvasectomy. The tests were the Arthus reaction by footpad swelling response 3 hours following footpad injection of syngeneic spermatozoa, and the release of radioactivity from chromium labeled spermatozoa following incubation with experimental sera, indicating cytotoxic antibodies to spermatozoa. The presence of serum-mediated immunity specific to spermatozoa could be demonstrated only in the group of rats which underwent conventional abdominal vasectomy with ligation of the vas deferens. This group's footpad swelling response (p.01) and the chromium labeled results (p.001) were statistically significant.

Article Info

Journal

Fertility and sterility

Abbr.

Fertil Steril

ISSN

0015-0282

DOI

10.1016/s0015-0282(16)40456-5

Published

1974-06-00

Pages

515-20

Language

English

Region

United States

NLM ID

0372772

Subset

External Links

PubMed source DOI: 10.1016/s0015-0282(16)40456-5 View journal details

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