Metabolic effects of hypoglycemic sulfonylureas. 3. Effect of chlorpropamide on energy metabolism and ketogenesis in the isolated perfused rat liver.

Acetoacetates/metabolism Adenosine Diphosphate/metabolism Adenosine Monophosphate/metabolism Adenosine Triphosphate/metabolism Animals Chlorpropamide/pharmacology Energy Metabolism/drug effects Hydroxybutyrates/metabolism Hypoglycemia/chemically induced In Vitro Techniques Ketone Bodies/biosynthesis Ketones/metabolism Lactates/metabolism Liver/drug effects,metabolism Liver Glycogen/metabolism Male Oxidation-Reduction Oxygen Consumption/drug effects Perfusion Phosphates/metabolism Pyruvates/metabolism Rats Sulfonylurea Compounds/metabolism Urea/metabolism

Acetoacetates Hydroxybutyrates Ketone Bodies Ketones Lactates Liver Glycogen Phosphates Pyruvates Sulfonylurea Compounds Adenosine Monophosphate Adenosine Diphosphate Adenosine Triphosphate Urea Chlorpropamide