Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: role of adenosine deaminase.

Science (New York, N.Y.) ·Vol. 182 ·No. 4114 ·1973-11-23 ·Pages 836-7

Green H, Chan T

Abstract

In the presence of 10(-4) to 10(-5) molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

MeSH Terms

Adenosine/antagonists & inhibitors,pharmacology Adenosine Diphosphate/biosynthesis Adenosine Triphosphate/biosynthesis Adolescent Aminohydrolases/metabolism Animals Cell Line Cytosine Nucleotides/biosynthesis Female Fibroblasts Guanine Nucleotides/biosynthesis Guanosine Triphosphate/biosynthesis Humans Infectious Mononucleosis Lymphocytes Lymphoma Mice Pyrimidine Nucleotides/biosynthesis Uracil Nucleotides/biosynthesis Uridine/pharmacology

Chemicals

Cytosine Nucleotides Guanine Nucleotides Pyrimidine Nucleotides Uracil Nucleotides Adenosine Diphosphate Guanosine Triphosphate Adenosine Triphosphate Aminohydrolases Adenosine Uridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Green H

Chan T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.182.4114.836

Published

1973-11-23

Pages

836-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.182.4114.836 View journal details

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Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: role of adenosine deaminase.

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