Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin.

Alkanes/chemical synthesis,pharmacology Amidines/chemical synthesis,pharmacology Anilides Animals Anticoagulants/chemical synthesis,pharmacology Arginine Benzoates Binding Sites Cattle Chromatography, Gel Humans Kallikreins/antagonists & inhibitors Pancreas/enzymology Phenyl Ethers/chemical synthesis,pharmacology Protein Binding/drug effects Structure-Activity Relationship Thrombin/antagonists & inhibitors Trypsin Inhibitors/chemical synthesis,pharmacology

Alkanes Amidines Anilides Anticoagulants Benzoates Phenyl Ethers Trypsin Inhibitors Arginine Kallikreins Thrombin