Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat.

British journal of pharmacology ·Vol. 49 ·No. 3 ·1973-11-00 ·Pages 534-42

Main IH, Whittle BJ

Abstract

1. Gastric mucosal blood flow was studied in the rat by means of a [(14)C]-aniline clearance technique.2. There was a significant correlation between clearance and stimulated acid secretion.3. No significant difference was found in the relationship between clearance and acid secretion during submaximal stimulation with either pentagastrin or histamine.4. Estimates of mucosal blood flow per unit acid secretion by [(14)C]-aniline clearance in the rat were similar to those reported with aminopyrine clearance in the dog and cat.

MeSH Terms

Aminopyrine/metabolism Aniline Compounds/metabolism Animals Blood Flow Velocity Carbon Radioisotopes Female Gastric Juice/metabolism Gastric Mucosa/blood supply Histamine/pharmacology Pentagastrin/pharmacology Rats Secretory Rate/drug effects

Chemicals

Aniline Compounds Carbon Radioisotopes Aminopyrine Histamine Pentagastrin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Main I H

Whittle B J

References (14)

14 references, click to expand

Gastric secretion in relation to mucosal blood flow studied by a clearance technic.
J Clin Invest. 1966 Jan;45(1):1-13 PMID: 5901177
Gastric blood flow and secretion in conscious dogs.
Am J Physiol. 1967 Apr;212(4):891-6 PMID: 6024455
Gastric blood flow in anaesthetized cats.
J Physiol. 1968 Feb;194(3):795-807 PMID: 5636998
Comparison of gastrin and histamine on gastric mucosal blood flow.
Proc Soc Exp Biol Med. 1969 Feb;130(2):484-6 PMID: 5765283
Gastric mucosal blood flow during secretory inhibition by gastrin pentapeptide and gastrone.
Gastroenterology. 1969 Apr;56(4):659-65 PMID: 4241698
Effects of secretory inhibitors on mucosal blood flow in nonsecreting stomach of conscious dogs.
Am J Physiol. 1970 Jan;218(1):270-4 PMID: 5409885
Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation.
Proc Soc Exp Biol Med. 1970 Feb;133(2):516-9 PMID: 4391836
Mucosal blood flow in canine antral and fundic pouches.
Gastroenterology. 1971 Feb;60(2):263-71 PMID: 5549266
Radioactive aniline clearance from canine gastric pouches for the measurement of gastric mucosal blood flow.
Br J Pharmacol. 1971 Feb;41(2):384P PMID: 5572287
Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.
J Physiol. 1971 Dec;219(3):571-85 PMID: 5157593
The measurement of dog gastric mucosal blood flow by radioactive aniline clearance compared with amidopyrine clearance.
J Physiol. 1973 Feb;229(1):115-31 PMID: 4689959
Proceedings: Effects of prostaglandin E2 on rat gastric mucosal blood flow, as determined by 14C-aniline clearance.
Br J Pharmacol. 1972 Feb;44(2):331P-332P PMID: 4668604
The gastric secretion of drugs: a pH partition hypothesis.
J Pharmacol Exp Ther. 1957 Mar;119(3):361-9 PMID: 13417090
Continuous recording of acid gastric secretion in the rat.
Br J Pharmacol Chemother. 1958 Mar;13(1):54-61 PMID: 13523135

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1973.tb17264.x

Published

1973-11-00

Pages

534-42

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1776483

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1973.tb17264.x PMC Full Text View journal details

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Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat.

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