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PMID: 4772277 Published · ppublish English Journal Article

An explanation of the asymmetric binding of sugars to the human erythrocyte sugar-transport systems.

The Biochemical journal ·Vol. 135 ·No. 3 ·1973-11-00 ·Pages 539-41

Barnett JE, Holman GD, Munday KA

Abstract

6-O-Alkyl-d-galactoses competitively inhibit the erythrocyte sugar-transport system when added to the outside of the cells, but not to the inside. n-Propyl beta-d-glucopyranoside competitively inhibits the system on the inside of the cells, but not on the outside. A model for sugar transport is proposed.

MeSH Terms
1-Propanol/pharmacology Binding Sites Biological Transport, Active/drug effects Carbohydrate Metabolism Carbohydrates/blood Cell Membrane/metabolism Depression, Chemical Erythrocytes/drug effects,metabolism Galactose/pharmacology Glucose/metabolism Glycosides/pharmacology Humans In Vitro Techniques Models, Biological Sorbose/metabolism
Chemicals
Carbohydrates Glycosides 1-Propanol Glucose Sorbose Galactose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Barnett J E
Holman G D
Munday K A
References (16)
16 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1350539
Published
1973-11-00
Pages
539-41
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1165857
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1350539 PMC Full Text View journal details
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