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PMID: 4758830 Published · ppublish English Journal Article

Bactericidal effect of combinations of nalidixic acid and various antibiotics on Enterobacteriaceae.

Antimicrobial agents and chemotherapy ·Vol. 4 ·No. 3 ·1973-09-00 ·Pages 201-4

Michel J, Luboshitzky R, Sacks T

Abstract

The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergistic than antagonistic, whereas with the other antibiotics the combination was more often antagonistic than synergistic. Synergistic effects were more common with Shigella than with other genera. In vitro examination for synergism or antagonism appears to be advisable before nalidixic acid is used therapeutically in combination with other antimicrobial agents.

MeSH Terms
Anti-Bacterial Agents/pharmacology Drug Combinations Drug Resistance, Microbial Drug Synergism Enterobacteriaceae/drug effects Microbial Sensitivity Tests Nalidixic Acid/pharmacology Shigella/drug effects
Chemicals
Anti-Bacterial Agents Drug Combinations Nalidixic Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Michel J
Luboshitzky R
Sacks T
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25 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.4.3.201
Published
1973-09-00
Pages
201-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444529
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.4.3.201 PMC Full Text View journal details
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