Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.

Science (New York, N.Y.) ·Vol. 180 ·No. 4085 ·1973-05-04 ·Pages 511-3

Crapper DR, Krishnan SS, Dalton AJ

Abstract

Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.

MeSH Terms

Aluminum/analysis,cerebrospinal fluid,metabolism,pharmacology Animals Avoidance Learning/drug effects Brain/metabolism,pathology Brain Chemistry Brain Diseases/chemically induced Cats Cerebellum/metabolism Cerebral Cortex/analysis,metabolism Dementia/metabolism,pathology Hippocampus/metabolism Humans Medulla Oblongata/analysis Optic Nerve/analysis Spinal Cord/metabolism Thalamus/analysis

Chemicals

Aluminum

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Crapper D R

Krishnan S S

Dalton A J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.180.4085.511

Published

1973-05-04

Pages

511-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.180.4085.511 View journal details

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Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.

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