Meiotic maturation in Xenopus laevis oocytes initiated by insulin.

Science (New York, N.Y.) ·Vol. 205 ·No. 4413 ·1979-09-28 ·Pages 1397-9

El-Etr M, Schorderet-Slatkine S, Baulieu EE

Abstract

Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.

MeSH Terms

Animals Calcium/physiology Cholera Toxin/pharmacology Cycloheximide/pharmacology Ethinyl Estradiol/pharmacology Female Insulin/pharmacology Kinetics Meiosis/drug effects Oocytes/drug effects Oogenesis/drug effects Ovum/drug effects Progesterone/pharmacology Receptor, Insulin/drug effects Xenopus

Chemicals

Insulin Ethinyl Estradiol Progesterone Cholera Toxin Cycloheximide Receptor, Insulin Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

El-Etr M

Schorderet-Slatkine S

Baulieu E E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.472755

Published

1979-09-28

Pages

1397-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.472755 View journal details

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