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PMID: 4719210 Published · ppublish English Journal Article

Asymptomatic primary biliary cirrhosis.

Gut ·Vol. 14 ·No. 6 ·1973-06-00 ·Pages 444-7

Fox RA, Scheuer PJ, Sherlock S

Abstract

Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from rheumatoid arthritis. Two patients showed normal skin and serological test responses to dinitrochlorobenzene and haemocyanin. These four patients are believed to be suffering from asymptomatic primary biliary cirrhosis.

MeSH Terms
Adult Alkaline Phosphatase/blood Antibodies Arthritis, Rheumatoid/complications,immunology Bile Ducts/pathology Biopsy Female Hemocyanins Humans Lectins Liver/pathology Liver Cirrhosis, Biliary/blood,complications,enzymology,immunology Lymphocyte Activation Middle Aged Mitochondria/immunology Nitrobenzenes
Chemicals
Antibodies Lectins Nitrobenzenes Hemocyanins Alkaline Phosphatase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fox R A
Scheuer P J
Sherlock S
References (11)
11 references, click to expand
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  9. Impaired delayed hypersensitivity in primary biliary cirrhosis.
    Lancet. 1969 May 10;1(7602):959-62 PMID: 4180814
  10. Mitochondrial antibodies and subclinical liver disease.
    Q J Med. 1970 Jan;39(153):31-48 PMID: 4193516
  11. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS.
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.14.6.444
Published
1973-06-00
Pages
444-7
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412729
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.14.6.444 PMC Full Text View journal details
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