Labile inhibitor of lymphocyte transformation in plasma from a patient and subacute sclerosing panencephalitis.

Infection and immunity ·Vol. 8 ·No. 1 ·1973-07-00 ·Pages 80-2

Allen J, Oppenheim J, Brody JA, Miller J

Abstract

A thermolabile inhibitory factor of mitogen-induced lymphocyte transformation was observed in the fresh plasma of one patient in stage 3 of subacute sclerosing panencephalitis (SSPE) and not in three other patients in various stages of the disease. Thus, its relevance to SSPE is not clear. The plasma factor was removed by adsorption onto human and animal cells and polystyrene beads, and it was found in the 7S globulin fraction of the effluent from gel permeation chromatography.

MeSH Terms

DNA/biosynthesis Encephalitis/blood,etiology,immunology Humans Immunity, Cellular Immunoglobulin A/isolation & purification Immunoglobulin E/isolation & purification Immunoglobulin G/isolation & purification Immunoglobulin M/isolation & purification Immunoglobulins/isolation & purification Lymphocyte Activation Measles/blood,complications,immunology Mitogens

Chemicals

Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Mitogens Immunoglobulin E DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Allen J

Oppenheim J

Brody J A

Miller J

References (10)

10 references, click to expand

The effect of uremic plasma on lymphocyte transformation.
Invest Urol. 1967 Sep;5(2):195-9 PMID: 6052955
Effect of plasma from patients with carcinoma on in vitro lymphocyte transformation.
Cancer. 1967 Dec;20(12):2088-9 PMID: 5624179
Measles as an index of immunological function.
Lancet. 1968 Sep 14;2(7568):610-3 PMID: 4175162
Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis.
N Engl J Med. 1969 Sep 11;281(11):585-9 PMID: 4980073
Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy.
Cell Immunol. 1972 Jul;4(3):228-42 PMID: 4402568
Serum inhibitors of lymphocyte responses.
Lancet. 1971 Jun 26;1(7713):1351-2 PMID: 4103410
Progressive increase in cerebrospinal fluid measles antibody levels in subacute sclerosing panencephalitis.
Pediatrics. 1971 Apr;47(4):782-3 PMID: 5089768
Subtle immunologic abnormalities in four boys with subacute sclerosing panencephalitis.
N Engl J Med. 1971 Jul 8;285(2):78-82 PMID: 4933967
Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies.
Science. 1971 Aug 27;173(3999):840-1 PMID: 4937231
In vitro effects of measles virus on proliferating human lymphocytes.
J Immunol. 1971 May;106(5):1154-8 PMID: 5574402

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.8.1.80-82.1973

Published

1973-07-00

Pages

80-2

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422813

Subset

External Links

PubMed source DOI: 10.1128/iai.8.1.80-82.1973 PMC Full Text View journal details

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Labile inhibitor of lymphocyte transformation in plasma from a patient and subacute sclerosing panencephalitis.

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