Control of pyrimidine biosynthesis in human lymphocytes. Inhibition of pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes by external uridine and its inhibition mechanism.

Aspartate Carbamoyltransferase/metabolism Aspartic Acid/biosynthesis,isolation & purification Azauridine/pharmacology Bicarbonates/metabolism Carbamates/biosynthesis,isolation & purification Carbon Dioxide/metabolism Carbon Isotopes Humans Lectins/pharmacology Lymphocytes/drug effects,enzymology,metabolism Nucleic Acids/biosynthesis Phosphoric Acids/biosynthesis Phosphotransferases/antagonists & inhibitors,metabolism Pyrimidines/biosynthesis Tritium Uracil Nucleotides/biosynthesis,isolation & purification Uridine/metabolism,pharmacology

Bicarbonates Carbamates Carbon Isotopes Lectins Nucleic Acids Phosphoric Acids Pyrimidines Uracil Nucleotides Tritium Carbon Dioxide Aspartic Acid Azauridine Aspartate Carbamoyltransferase Phosphotransferases Uridine