Role of delayed hypersensitivity in blastomycosis of mice.

Infection and immunity ·Vol. 7 ·No. 3 ·1973-03-00 ·Pages 329-34

Spencer HD, Cozad GC

Abstract

C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 x 10(4) viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells.

MeSH Terms

Animals Antigens, Fungal Blastomyces/immunology Blastomycosis/immunology Fungal Vaccines Hypersensitivity, Delayed Immunity Immunization Immunization, Secondary Mice Mice, Inbred C57BL Rodent Diseases/immunology Vaccines, Attenuated

Chemicals

Antigens, Fungal Fungal Vaccines Vaccines, Attenuated

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Spencer H D

Cozad G C

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.7.3.329-334.1973

Published

1973-03-00

Pages

329-34

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422679

Subset

External Links

PubMed source DOI: 10.1128/iai.7.3.329-334.1973 PMC Full Text View journal details

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Role of delayed hypersensitivity in blastomycosis of mice.

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