On the molecular action of local anesthetics. 1. The mitochondrian as a model membrane system for studying local anesthetic action.

Anesthetics, Local/pharmacology Animals Dose-Response Relationship, Drug Histones/administration & dosage,pharmacology In Vitro Techniques Male Membranes/drug effects Microscopy, Electron Mitochondria, Liver/drug effects Mitochondrial Swelling/drug effects Models, Biological Potassium/metabolism Procaine/pharmacology Proteins/pharmacology Rats Structure-Activity Relationship Time Factors Valinomycin/pharmacology

Anesthetics, Local Histones Proteins Valinomycin Procaine Potassium