Metoclopramide in gastrooesophageal reflux.

Gut ·Vol. 14 ·No. 4 ·1973-04-00 ·Pages 275-9

Stanciu C, Bennett JR

Abstract

In 30 patients with gastrooesophageal reflux, intravenous metoclopramide (Maxolon) has been shown to increase the gastrooesophageal sphincter pressure. The rise is dose-related until a maximum pressure, proportional to the resting sphincter tone, is reached. The effect is reversed by atropine. Peristaltic waves are increased in pressure by metoclopramide.In 18 patients with gastrooesophageal reflux intravenous metoclopramide diminished the frequency of reflux episodes and increased the rate at which the oesophagus emptied itself of an acid load.

MeSH Terms

Adolescent Adult Aged Amides/antagonists & inhibitors,therapeutic use Anisoles/antagonists & inhibitors,therapeutic use Atropine/pharmacology Benzoates/antagonists & inhibitors,therapeutic use Catheterization Dose-Response Relationship, Drug Esophagus/physiopathology Ethylamines/antagonists & inhibitors,therapeutic use Female Gastroesophageal Reflux/prevention & control Humans Hydrogen-Ion Concentration Injections, Intravenous Male Middle Aged Pressure Stomach/physiopathology

Chemicals

Amides Anisoles Benzoates Ethylamines Atropine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stanciu C

Bennett J R

References (7)

7 references, click to expand

[Action of methoclopramide on different portions of isolated rabbit intestine and on the "in situ" intestine].
Pathol Biol. 1966 Oct;14(19):963-5 PMID: 5339616
Acid clearing from the distal esophagus.
Arch Surg. 1968 May;96(5):731-4 PMID: 5653000
Gastrointestinal effects of metoclopramide in man. In vitro experiments with human smooth muscle preparations.
Br Med J. 1968 Dec 14;4(5632):679-80 PMID: 5723387
Assessment of distal esophageal function in patients with hiatal hernia and-or gastroesophageal reflux.
Ann Surg. 1970 Oct;172(4):627-37 PMID: 5458619
The effect of metoclopramide on the gastroesophageal junctional zone and the distal esophagus in man.
Scand J Gastroenterol. 1970;5(7):620-6 PMID: 5474434
Effect of intravenous metoclopramide on gastrooesophageal reflux.
Gut. 1972 Jan;13(1):31-2 PMID: 5060665
A MULTIPHASE ESOPHAGEAL PH TEST FOR GASTROESOPHAGEAL REFLUX.
Surgery. 1965 May;57:638-46 PMID: 14295772

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.14.4.275

Published

1973-04-00

Pages

275-9

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1412597

Subset

External Links

PubMed source DOI: 10.1136/gut.14.4.275 PMC Full Text View journal details

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