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PMID: 46898 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Induction of blood eosinophilia by pulmonary embolization of antigen-coated particles: the relationship to cell-mediated immunity.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 4 ·1975-04-00 ·Pages 1348-53

Schriber RA, Zucker-Fraklin D

Abstract

A method of immunization has been described which consists of the i. v. injection into rats of large latex particles coated with human gamma-globulin (HGG). The coated particles embolize the pulmonary capillary bed and induce blood eosinophilia, which correlated strongly with the development of lymphocyte responsiveness to HGG in vitro. Sequential histologic studies of the lungs including ultrastructural analysis suggest a delayed hypersensitivity reaction to the coated particles. These studies support the concept that the induction of blood eosinophilia may be mediated by T lymphocytes.

MeSH Terms

Animals Carbon Radioisotopes Cells, Cultured Eosinophilia/etiology Eosinophils Germ-Free Life Humans Immunity, Cellular Immunization Latex Latex Fixation Tests Leukocyte Count Lung/ultrastructure Lymphocyte Activation Male Microscopy, Electron Microspheres Passive Cutaneous Anaphylaxis Pulmonary Embolism/complications Rats Thymidine/metabolism gamma-Globulins

Chemicals

Carbon Radioisotopes Latex gamma-Globulins Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schriber R A

Zucker-Fraklin D

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-04-00

Pages

1348-53

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Induction of blood eosinophilia by pulmonary embolization of antigen-coated particles: the relationship to cell-mediated immunity.

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