Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. II. Isolation and characterisation of the olivanic acids MM 4550, MM 13902 and MM 17880 from Streptomyces olivaceus.

The Journal of antibiotics ·Vol. 32 ·No. 4 ·1979-04-00 ·Pages 295-304

Hood JD, Box SJ, Verrall MS

Abstract

The olivanic acids MM 4550, MM 13902 and MM 17880 are members of a new family of beta-lactam antibiotics. An isolation and purification process utilising ion-par extraction and ion-exchange chromatography is described and the metabolites are characterised by physico-chemical and biological properties.

MeSH Terms

Anti-Bacterial Agents/biosynthesis,isolation & purification,pharmacology Bacteria/drug effects Chemical Phenomena Chemistry, Physical Fermentation Streptomyces/metabolism beta-Lactams/biosynthesis,isolation & purification,pharmacology

Chemicals

Anti-Bacterial Agents beta-Lactams

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hood J D

Box S J

Verrall M S

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.32.295

Published

1979-04-00

Pages

295-304

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.32.295 View journal details

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Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. II. Isolation and characterisation of the olivanic acids MM 4550, MM 13902 and MM 17880 from Streptomyces olivaceus.

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