Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.

Infection and immunity ·Vol. 24 ·No. 3 ·1979-06-00 ·Pages 958-61

Sato H, Ito A, Yamakawa Y, Murata R

Abstract

A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.

MeSH Terms

Animals Mice Neutralization Tests Subtilisins Tetanus/etiology,pathology Tetanus Antitoxin/administration & dosage,pharmacology Tetanus Toxin/toxicity

Chemicals

Tetanus Antitoxin Tetanus Toxin Subtilisins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sato H

Ito A

Yamakawa Y

Murata R

References (7)

7 references, click to expand

Structure of tetanus toxin. II. Toxin binding to ganglioside.
J Biol Chem. 1977 Jan 10;252(1):194-8 PMID: 64469
Antigenic substructure of tetanus neurotoxin.
Biochem Biophys Res Commun. 1977 Jul 11;77(1):268-74 PMID: 407907
Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments.
J Biol Chem. 1977 Jan 10;252(1):187-93 PMID: 401808
Toxicity of papain-digested tetanus toxin. Pathological effect of fragment B in the absence of spastic paralysis.
J Biol Chem. 1978 Jan 10;253(1):125-9 PMID: 563395
Studies on tetanus antitoxins. II. Demonstration of at least four antitoxins of different specificity in antitoxic sera.
J Immunol. 1973 May;110(5):1388-95 PMID: 4633299
Ganglioside as a prophylactic agent in experimental tetanus in mice.
J Gen Microbiol. 1968 Dec;54(2):161-8 PMID: 4891919
Isolation and purification of two antigenically active, "complimentary" polypeptide fragments of tetanus neurotoxin.
Infect Immun. 1975 Nov;12(5):1147-53 PMID: 1104484

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.24.3.958-961.1979

Published

1979-06-00

Pages

958-61

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414401

Subset

External Links

PubMed source DOI: 10.1128/iai.24.3.958-961.1979 PMC Full Text View journal details

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Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.

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